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Ref : ESF-4969
Posting date : 30/07/2010
Deadline for application : 31/12/2010
Employer : INSERM U895, Equipe 7
Contract : Fixed-term
Location : NICE,
Provence-Alpes-Côte d'Azur,
France
Salary : 2539.39 euros brut
A two years post-doctoral position funded by the French Research Agency (ANR) is available in Team 7 “Cellular and Molecular Pathophysiology of Obesity and Diabetes” of INSERM U895, Mediterranean Research Center for Molecular Medicine located in the city of Nice, France. This position will start on January 2011.
The scientific project that we developed in the team has two major objectives. The first one is to identify the cellular and molecular mechanisms involved in insulin resistance induced by adipose tissue inflammatory and hypoxic stresses. The second one is to understand the pathophysiological mechanisms responsible for the association between obesity and the occurrence of cancer. Our team utilizes multidisciplinary approaches including human and mouse cell culture, animal model, molecular biology, imaging technologies, metabolism and signaling studies in isolated muscles and adipocytes. For more informations on the team see: http://webs.unice.fr/c3m/FR/Equipe7.html.
 Details
The project will focus on the implication of a new inflammatory kinase recently identified by the team in the development of adipose tissue and liver inflammation and insulin resistance. The project will combine both cellular approaches and the phenotypic characterization of mice with global or specific invalidation of this kinase. The impact of the modulation of this kinase on the behavior of immune cells during the development of obesity will be also investigated.
Candidate profile
The candidate should have his/her PhD. Ideally, the candidate should have an expertise in the field of metabolic diseases; an expertise in immune response will be a bonus. Experience in cell signaling and in the study of metabolism in mouse models is necessary.
Application process
Interested candidates should e-mail a CV, a cover letter outlining their past and present research interests, and names and contact information of at least two references to:
Dr Jean-François TANTI
E-mail: tanti@unice.fr / Phone : +33 4 89064237/ Fax +33 4 89064221
INSERM U895, Team 7, Batiment Archimed, 151 route de St Antoine de Ginestière, 06204, Nice Cedex 3.
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